![]() ![]() The OSMED 2021 report on the use of drugs in Italy hasĮstimated that the average consumption of these drugs is overĥ0 DDD per 1000 inhabitants/day. ![]() Of category C, the consumption data are available only through Because theyĪre not reimbursable by the national health system as they are Pharmaceutical packages (including generics). There are about 30 active ingredients on the market with over 350 In Italy theyĪre classified as neuro-active, sedative-hypnotic drugs, of which General population or about 3 million people. That chronic consumers, therefore off-label, are about 5% of the In all European Union countries and, in Italy, it is estimated Introductionīenzodiazepines (BDZ) are among the most prescribed drugs In Italy this approach is still used to a limited extent and it cannot be said that it is absolutely the best method but the analysis of various endpoints in published studies, such as acute withdrawal discomfort, discharge without prescription of benzodiazepines and relapses in the first 6-12 months of discharge, certainly makes us reflect on the possibility of extending this approach to various territorial hospitals. This would allow the GABA-Argic receptor resensitization in a short time and with minimal or absent withdrawal symptoms, being able to suspend megadoses of BDZ in a very short time. Both Italian and international research articles have been selected, starting from 1980 to today.ĭiscussion and Conclusions: The use of flumazenil in slow infusion remains off-label but, for almost 20 years, it has been in use (in Italy and beyond) to detoxify, in about a week of hospitalization, patients with equivalent daily doses of diazepam greater than 50 mg / day for more than 6 months (with a description of cases up to 350 mg / day of diazepam-equivalent). We also used the PUBCHEM database to describe some chemical and pharmacological characteristics of flumazenil. Materials and Methods: A computerized research was carried out for the articles to be inserted through use of international databases PUBMED and RESEARCHGATE by typing in keywords such as “flumazenil, high dose benzodiazepine users, use of flumazenil for benzo detoxification” and related articles. ![]() The purpose of the article is, starting from the pharmacological and biochemical bases, to describe the mechanism of action, the areas of applicability and the possible criticalities by analyzing the Italian data. In recent years, the off-label use of continuous infusion subcutaneous flumazenil has established itself as a viable approach for rapid hospital detoxification of these sometimes very complex clinical cases. Unfortunately, 40 to 80% of the LTUs develop dependence and many also have tolerance, with the need for a progressive increase in the daily dosage up to the point of tolerating daily megadoses. Introduction: The use of benzodiazepines (BDZ) is notoriously associated with significant long-term problems and it is estimated that the long-term users (LTU) in Italy are over 3 million people, including many elderly people. Use of Flumazenil in Detoxification of High-Dose Benzodiazepine Users: A Mini Review of Pharmacological Basis and Clinical StudiesĪuthor(s): Amelia Morgillo*, Caterina Rosaria Morgillo, Angela Cambareri and Edoardo Marovino Abstract ![]()
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![]() Most animal proteins - such as eggs, beef, pork, poultry, and seafood - are low in carbs and appropriate for the keto diet.Ĥ–7. This includes the antioxidants lutein and zeaxanthin, which protect eye health ( 26).Īlthough egg yolks are high in cholesterol, they don’t appear to increase your risk of heart disease ( 27). It’s important to eat whole eggs rather than egg whites since most of an egg’s nutrients are found in the yolk. In addition, eggs have been shown to trigger hormones that increase feelings of fullness ( 25). EggsĮggs are an extremely healthy protein source.īecause each large egg contains less than 1 gram of carbs and about 6 grams of protein, eggs can be ideal for keto ( 24). It may be best to choose grass-fed meat, if possible, since it has more omega-3 fats and conjugated linoleic acid (CLA) than meat from grain-fed animals ( 22, 23). One small study in older women found that a diet high in fatty meat led to 8% higher levels of HDL (good) cholesterol than a low fat, high carb diet ( 21). They’re also a great source of high quality protein, which may help preserve muscle mass during a very low carb diet ( 18, 19, 20). Meat and poultry are considered staple foods on the keto diet.įresh meat and poultry contain no carbs and are rich in B vitamins and several important minerals. The American Heart Association recommends that adults over 18 years old eat 8–10 ounces of seafood per week ( 17). ![]() You can still eat these foods on the keto diet, but it’s important to carefully track these carbs to stay within your range ( 10, 11, 12, 13).Īdditionally, salmon, sardines, mackerel, and other fatty fish are very high in omega-3 fats, which have been associated with lower insulin levels and increased insulin sensitivity in people who are overweight or have obesity ( 14).įrequent fish intake is linked to improved brain health and a decreased risk of disease ( 15, 16). While shrimp and most crabs contain no carbs, oysters and octopus do. However, the carb count in shellfish varies by type. Salmon and other fish are not only nearly carb-free but also rich in B vitamins, potassium, and selenium ( 9). Seafoodįish and shellfish are very keto-friendly. ![]() Share on Pinterest Healthline/Aya Brackett 1. ![]() ![]() ![]()
![]() ![]() In fact if you really want to work with parametric EQ a lot, and you like this, it’s probably worth buying FabFilter’s stuff. So the UI borrows very, very liberally from FabFilter’s Pro-Q 3, which in fact does a lot more (like surround sound, 24 bands, EQ matching). Note the relation of filter algorithms to Ableton Live’s excellent EQ8 (Andy Simper/Cytomic). If you like the visualization, you can also use the spectrum analyzer version of the same even when not EQing. Experts and beginners alike I think will find both creative sound design and composition applications, and precision mixing and mastering uses. It’s a labor of love, and it shows – that love comes your way. There are now analog-modeled low and high channel filter modes, 16 filter nodes (instead of 8), better performance on Windows, and – crucially – a PDF manual so you know what in the heck is going on.Īnd did I mention this is free / donationware? (So do put something in that hat, eh?) It’s even under a generous MIT open source license. So while this is old news in one sense (2018), even the last few months have brought new improvements. I’m aware my screenshots make no sense but I’m tired and – this UI is just too pretty not to make pictures with it. But it’s tough to find anything with this many shortcuts, handy features, and audio options – and the developer just keeps adding more. Yes, there are other powerful EQs like this out there. ReEQ us a feature-laden parametric EQ that covers all the bases. ![]() Just one example – this free sixteen-band EQ and spectrum analyzer, created by a user in Reaper’s JSFX*, for free, does just about everything. Cockos’ REAPER is the stupidly affordable but endlessly customizable DAW. ![]() ![]() ![]() While the exact extent of Deadmau5's announcement was unclear, in July 2012 he announced that there would be a shoot for a music video to go along with "Professional Griefers", and that he needed around 2000 fans to come and act as extras for the video. ![]() Deadmau5's response explained that he intended on doing releasing "Professional Griefers" alongside something huge. Fans were thrilled by the announcement of Deadmau5's collaboration with Gerard in early 2012, but questioned why he was holding back the release of "Professional Griefers" as a single. Soon, a collaboration was born, and Deadmau5 worked with Gerard Way, using his vocals to add to his song. Deadmau5 would put on a show that received critical acclaim, having used what he would come to call his 'Expert Griefing Machine', despite having changed the song's name.ĭeadmau5 at the helm of the Expert Griefing Machine In this form, "Professional Griefers" was a mere instrumental track, which Deadmau5 unleashed upon his fans during his Meowington Hax Tour as part of his headlining performance at Lollapalooza. Over time, Deadmau5 altered his song, and thus changed "Expert Griefers" into "Professional Griefers". Thank you for this beautiful song! No one can argue with thatInitially, Deadmau5 previewed a new unreleased track under the name "Expert Griefers" through Deadmau5's Ustream account toward the beginning of 2011. It's a testament to how dark our thoughts can be, and to the demon that is depression. He says he will pretend which is what he has been doing while this melody has played over and over in his head. He gives it away when he says I'll pretend to be happy instead of using "you". "I'll pretend to be happy, and I don't care, You cry yourself to sleep, and I don't care."This is kind of a give away for my interpretation, because this song has so many notes of being disappointed in himself. Our thoughts really determine how we feel about ourselves. It's simple and melodic, a haunting melody that would be found in someone's head. It's not vengeful as it may be for an ex. And the background track reflects that as well. ![]() When I heard this immediately, I thought, yes, this is far deeper than a breakup. It's likely a combination of self-hatred and words cast upon him by others. Another interpretation is that these could be words people said to him that he has internalized, and he has let them become a part of his personage. He refers to this breaking point when writes, "You knew this day would come, and you did, and you really should have waited". It's that breaking point where you give up on trying to understand your feelings or your position in life. The writer is venting his frustrations with himself, but is so upset that he can't or doesn't really desire to change where he is at. The way the song is written repetitively suggests that this is an internal dialogue. It's a poem to one's self, a sad one at that. This song kills me everytime I hear it mainly because of the way I read it. You knew this day would come, and it did, and you should have waited I'll pretend to be happy, and I don't care You contradict everything, and I don't care You knew this day would come, and it did, and you really should have waited ![]() Go cry yourself to sleep, and you should, because I'm so faded You knew this day would come, and you did, and you really should have waited You're wasting our time, and I don't care You cry yourself to sleep, and I don't care You're a walking disaster, and I don't care You're weak and you're gullible, and I don't care ![]() ![]() À exprimer le désir, la volonté, l’exigence (vouloir, exiger) ou un sentiment (souhaiter, avoir envie…) dans une subordonnée (qui dépend donc d’une principale).Įx : Je veux/Je souhaite/J’exige/J’ai envie que tout le monde soit heureux. Ex : Qu’il vienne immédiatement ! (ordre) – Que tout le monde soit heureux ! (souhait) À exprimer l’ordre ou le souhait dans une proposition indépendante. (For the extra-extra-mile, as a simple French curiosity, there’s one last use of l’imparfait: l’imparfait “hypocoristique” = using l’imparfait in place of the present tense, to sound like you’re talking like a child, for endearment.)Īlors, c’est un peu complexe mais j’espère que cette réponse t’aidera un peu : = She was in the middle of walking out of the bakery. Elle était en train de sortir de la boulangerie. = I am currently in the middle of eating. For instance: Je suis en train de manger. *** Le truc en plus *** For long actions (= progressive tenses), you can also use the everyday expression “ être en train de” = to be in the middle of. → Here, “ Elle allait” is a long action compared to “ elle a vu.” “ Seeing Michel” cut short her action of “ going to the bakery.” That’s why we use l’imparfait for “ elle allait,” and le passé composé for “ elle a vu Michel.” Le passé composé is the other main French tense for the past, and it’s used for short actions (that we take as a whole, rather than as a period of time.) = She was going to the bakery when she saw Michel. = I was already in Grenoble last year.Īnd for long actions in the past: Elle allait à la boulangerie, quand elle a vu Michel. Like: J’étais déjà à Grenoble l’année dernière. More generally, it’s used for situations in the past (that lasted some time). = I used to drive to the office every morning. J’allais au bureau en voiture tous les matins. ![]() Well, that’s the second meaning of l’imparfait : a habit, in the past. Il y a (there is) → il y avait (there was / there used to be) Il faut (Someone needs to…) → Il fallait (Someone needed to…) Il pleut (it’s raining) → il pleuvait (it was raining) Il neige (it’s snowing) → il neigeait (it was snowing)ĭid you notice? In the examples above, I sometimes translated l’imparfait with “ used to. ![]() Some impersonal verbs don’t always have a present form with “ nous” yet we still use them in l’imparfait. ![]() Most notably: Commencer(= to start) → Nous commençons (= we start, present) → In l’imparfait: Je commençais Nous commencions Tu commençais Vous commenciez Elle commençait Elles commençaient So it always sounds like “ss” (as in “ ça” or “ ce”) and never like “ k” (as in “ ca” or “ co”). We add la cédille ( ç) for all subjects with -ai. Most notably: Manger (= to eat) → Nous mangeons (= we eat) → In l’imparfait: Je mangeais Nous mangions Tu mangeais Vous mangiez Elle mangeait Elles mangeaient Verbs in -ger add an -e before the endings of l’imparfait, with all subjects except “ nous” and “ vous.” Basically, we don’t want to hear the hard “ g” sound that would appear with “ g + ais.” So we turn it into “- geais” ![]() Fortunately, there aren’t many second-group verbs in everyday French ( grandir, nourrir = to feed…) – most verbs in -irare 3rd-group (like courir = to run, dormir = to sleep…) Unfortunately, there’s no real shortcut you have to learn the group of each verb in -ir you see.ī) Tweaks in first-group verbs, for pronunciation reasons ![]() ![]() ![]() Their approach holds promise for exploring new quantum-fluid regimes, including some that could serve as analog models of gravity. Now Ferdinand Claude of the Kastler-Brossel Laboratory (LKB) of Sorbonne University, France, and co-workers have provided an unprecedentedly detailed characterization of a quantum fluid of polaritons-quasiparticles resulting from the strong coupling of photons and excitons in a semiconductor microcavity. Our understanding of these exotic states, however, is hampered by experimental limitations-in particular, the difficulty of probing the collective excitations that are hallmarks of quantum-fluid behavior. Both configurations allow photons to acquire an effective mass and experience an effective mutual interaction-properties that can lead them to collectively behave as a quantum fluid. Two platforms emerged for the study of these “fluids of light”: semiconductor microcavities in which photons are confined and propagating geometries in which photons travel in a bulk medium. ![]() Over a decade ago, optics researchers started to take an interest in superfluids and other quantum fluids, driven by the realization that light propagating in a nonlinear medium can exhibit quantum hydrodynamics features. Superfluidity, the ability of a fluid to flow without friction, isn’t restricted to systems described by hydrodynamics. ![]() By measuring the cavity reflectivity for different incidence angles of a “probe” pulse, the team obtained the polariton dispersion curve. A “pump” laser pulse (red) generated polaritons via photoexcitation. APS/ Alan Stonebraker Figure 1: Sketch of the “pump-probe” setup used by Claude and co-workers to characterize the fluid of polaritons in a semiconductor cavity. ![]() ![]() Try to just get the milk warm so it doesn’t develop a skin. Ingredient Tip: It’s important to avoid scalding the milk/half-and-half, which can happen very quickly. ![]() Then, infuse the syrup with plenty of lavender flowers.Ĭombine the steeped tea, lavender syrup (flowers strained).įroth the half-and-half: warm the cream in a saucepan and whisk vigorously for 30 seconds (about). I buy both caffeinated and decaffeinated tea so I can enjoy this drink in the morning and evening. Ready? Let’s make some tea! How to Make a London Fog Tea Latteįirst, steep the tea (you want the water to be boiling hot). sugar – I like a good amount of sugar in this particular recipe because it brings the floral flavor forward and without it, I think the drink would be a bit boring.I do this step with a whisk, so there’s no need for any special equipment, and it only takes a few seconds in a saucepan. frothing half-and-half takes this drink to the next level. a smooth mouthfeel – instead of whole milk, I gravitate toward half-and-half, which holds its froth longer because of the fat.a bold, sweet, and flowery cup – I steep dried lavender flowers along with Earl Grey Tea, which has notes of bergamot oil and edible blue cornflower petals (I like Tea and Company’s Earl Grey Creme Tea and this decaf Bigelow tea for nighttime).Here’s what makes this London Fog SO GOOD: It’s super easy to make but greater than the sum of its parts. What is a London Fog?Ī London Fog is a drink that combines Earl Grey tea and warm milk. I usually encourage you to play around with my recipes, but in this case, I think the proportions matter quite a bit. ![]() It’s a good thing I did, because I found a ton of variation in flavor from one test batch to the next. I totally reveled in testing this one over and over. Unlike the popular London Fog latte which originates in Canada, mine gets a lovely floral flavor from steeped lavender (vanilla is more traditional). It’s a rich, and somehow light, drink that begs to be sipped and savored. ![]() If you’re like me, and in need of some fresh tea inspiration, you will surely love this Earl Grey-frothed milk latte. I’m drawn in by mysterious drink names “London Fog” conjures cozy images of frothy, hot drinks and misty mornings. ![]() ![]() All the poker pros are doing it! It comes free with the poker guard order. To save your time, LuluCircle prepared a chip bag for you, so you can take the chips home with you and use them when you come to the poker room next time. We have noticed that changing chips at the cage is always super annoying, especially on Friday or Saturday nights when all the "fishes" are out there. CHIP BAG BONUSAt LuluCircle, most of us are regular poker players at casinos.The purpose of gilding is not only to make our Poker Guards more attractive and also to increase the duration of the use. GILDED IRONOur Poker Guards are made of iron with a thin coating of gold.- By offering you 1-year satisfaction guarantee and lifetime customer service, If you are unhappy about our Poker Cards, feel free to contact our.Spill milk or drink on it? No need to worry, our cards are waterproof and washable - This deck of cards gets a waterproof feature.And PET feels better as the material of playing cards It is very smooth surface, wrinkle-free, comfortable feel. ![]() - PET and PVC are waterproof.Our playing cards are made of superior flexible material.- Unlike those poker cards in the market, our non-slippery cards are easy to shuffle and thus cannot be missed by people who have some tricks up their sleeves.Perfect for family party, BBQ game, great for taking them as a gift to your friends or family We offer you the best and the most special poker playing cards available in the market. - Length x Width (3.45 2.25) 1 Deck: 54 cards standard deck.Feel more comfortable to hold these black playing cards.If there is a problem during transportation that prevents the wall clock from working properly, please consult customer service for replacement or refund. After receiving the goods, please open the package and check its integrity in time.In order to ensure unnecessary damage to the goods during transportation, the goods are guaranteed to be complete by strengthening the packaging before transportation.Wall clock is suitable for display on the wall of living room, bedroom, coffee shop or office. ![]() The hour hand is not easily deformed after being thickened.
![]() “We had a small budget, but we had the desire to do it,” said Dr. But our platform now will enable us to stream the data in real time from any source, process it, and provide analysis on it in an almost-real-time basis.” ImplementationĪs Rush implements its platform, elasticity is crucial. “Before we were waiting 24 to 48 hours to collect, process, and analyze data. We found that adding clinical notes to models doubled the accuracy of the models.”Īdded Khan, “We can write models on a larger set of data, and machine learning enables us to see exactly where the variations are and design our care paths along those variations,” said Khan. Tapping into the content of clinical notes-what doctors have written and what they mean-is also crucial. Bala Hota, chief analytics officer at Rush University Medical Center. “We started on this path for several reasons-genomics and precision medicine is a big one,” said Dr. In fact, with Cloudera and MetiStream, Rush ingested years of clinical notes into the platform in only 36 hours. With this platform, Rush is eliminating data silos and can analyze a much wider range of data in near-real time-from genomic data to medical device data to unstructured clinical notes and text data. Rush University Medical Center is working with Cloudera and MetiStream to implement machine learning and deploy analytics-as-a-service to hospital administrators, clinicians, and researchers. ![]() “We don't believe that we can do all the projects in our pipeline without a big data platform that can support new types of data, along with the growing volume and high velocity of data we want to analyze, ” said Khan. However, Rush needed a modern data platform to gain deeper, and faster, insights into patient care and healthcare delivery. “Data empowers us to understand the specific gene makeup of a given patient and what care path is best.” “To be data-driven is not an option anymore it is a requirement,” said Jawad Khan, director of Knowledge Management and Data Sciences at Rush University Medical Center. Rush University Medical Center, located in Chicago, Illinois, is a leading U.S. ![]() |
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